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KMID : 0982820020010010029
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Journal of Lung Cancer
2002 Volume.1 No. 1 p.29 ~ p.33
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Chemo-radiation Therapy for Locally Advanced Non-Small Cell Lung Cancer
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Oh Young-Taek
Chun Mi-Son
Choi Jin-Hyuk
Lim Ho-Yeong
Kang Seung-Hee
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Abstract
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Purpose: Chemotherapy, followed by radiation therapy, improves the survival of patients with locally advanced non-small cell lung cancer (NSCLC). However, it is not clear whether chemotherapy, followed by concurrent chemo-radiation therapy, can improve survivals compared to only concurrent chemo-radiation therapy. We conducted this study to evaluate the role played by induction chemotherapy followed by concurrent chemo-radiation therapy.
Materials and Methods: Between 1995 and 2000, 55 patients with locally advanced NSCLC were treated with concurrent chemo-radiation therapy. Twenty-seven patients received the induction chemotherapy prior to the chemo-radiation therapy, and their characteristics and survival compared.
Results: There were no significant differences in patient characteristics, with the exception of weight loss. The group receiving the induction chemotherapy showed a lesser weight loss, but with no statistical difference in the survival results.
Conclusion: No advantage was shown with the induction chemotherapy when followed by concurrent chemo-radiation therapy in the treatment of locally advanced NSCLC.
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KEYWORD
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NSCLC, CCRT, Unresectable
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